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pentobarbital will decrease the level or effect of tamoxifen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will lower the extent or effect of norgestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Reasonable CYP3A4 inducers may well decrease progestin concen